Transcutaneous and intradermal vaccination
نویسندگان
چکیده
منابع مشابه
Nanoparticles for transcutaneous vaccination
The living epidermis and dermis are rich in antigen presenting cells (APCs). Their activation can elicit a strong humoral and cellular immune response as well as mucosal immunity. Therefore, the skin is a very attractive site for vaccination, and an intradermal application of antigen may be much more effective than a subcutaneous or intramuscular injection. However, the stratum corneum (SC) is ...
متن کاملIntradermal vaccination for Mycoplasma hyopneumoniae
Results: Injection site reactions were minimal for all vaccines. Pigs vaccinated ID, either by needle or needleless injector, had significantly higher M hyopneumoniae antibody titers than did pigs vaccinated by IM injection. Pigs vaccinated by needleless ID injection had lower lung lesion scores and higher IgA and IgG titers in bronchoalveolar lavage fluid than did nonvaccinates following chall...
متن کاملDelivery systems for intradermal vaccination.
Intradermal (ID) vaccination can offer improved immunity and simpler logistics of delivery, but its use in medicine is limited by the need for simple, reliable methods of ID delivery. ID injection by the Mantoux technique requires special training and may not reliably target skin, but is nonetheless used currently for BCG and rabies vaccination. Scarification using a bifurcated needle was exten...
متن کاملTranscutaneous vaccination via laser microporation
Driven by constantly increasing knowledge about skin immunology, vaccine delivery via the cutaneous route has recently gained renewed interest. Considering its richness in immunocompetent cells, targeting antigens to the skin is considered to be more effective than intramuscular or subcutaneous injections. However, circumvention of the superficial layer of the skin, the stratum corneum, represe...
متن کاملComparison of Immune Responses following Intradermal and Intramuscular Rabies Vaccination Methods
Rabies is a zoonotic viral disease. The causative agent is a negative-sense RNA genome virus of the genus Lyssavirus (Family: Rhabdoviridae). The disease, commonly transmitted by rabid dogs, is the cause of mortality of over 59000 humans worldwide annually. This disease can be prevented before the development of symptoms through proper vaccination even after exposure. Hence, improvement of the ...
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ژورنال
عنوان ژورنال: Human Vaccines
سال: 2011
ISSN: 1554-8600,1554-8619
DOI: 10.4161/hv.7.8.16274